Heart rate variability as a marker of mast cell activation

Autonomic involvement

Mast cell activation frequently coincides with autonomic changes, and heart rate variability is a well-established, non-invasive proxy for autonomic state that a wearable can track continuously.

What we see

In continuous recordings, HRV shifts often accompany reported activation, and when combined with other signals they improve the separation between activation windows and baseline.

Context

HRV is influenced by many factors, so it is most useful as one channel within a multi-parametric model rather than a standalone marker.